The ENIGMA plasticity working group focusses on individual differences in longitudinal brain changes. All cohorts with longitudinal MRI and GWAS data are invited to join, irrespective of age or disease status. If you are interested to join, please contact Rachel Brouwer [r.m2.brouwer@vu.nl] or Hilleke Hulshoff Pol [h.e.hulshoffpol@uu.nl].

Previous projects:

• GWAS of longitudinal brain changes in > 15,000 participants covering the lifespan:
  • Brouwer RM, Klein M, Grasby KL, Schnack HG, Jahanshad N … Medland SE, Franke B, Thompson PM, Hulshoff Pol HE. Genetic variants associated with longitudinal changes in brain structure across the lifespan. Nat Neurosci, 2022.
  • Summary statistics can be requested here.
  • Cohort level protocols for imaging analysis & QC, imputation and cohort level analysis for this project can be found here.

• Heritability of changes in global and subcortical brain volumes using five longitudinal twin cohorts throughout the lifespan and from across the world:
  • Brouwer RM, Panizzon MS, Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, de Zubicaray GI, Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM, Hulshoff Pol HE. Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human brain mapping, 38:4444-4458, 2017.